TraQ Program of the BC PBCO

Home Continuing Education Case Studies B-Level Case B3: ABO Discrepancy Complicated by Transfusion
Monday, 29 August 2016

Case B3: ABO Discrepancy Complicated by Transfusion

Case Report


Mr. VT is a 50-year-old male who has been admitted for elective surgery following a car accident. He had been admitted to another hospital 4 weeks earlier following the accident.


  • Two units of red cells are ordered for the surgery.
  • Results

Discussion and Resolution


After reviewing the case resolution, answer these questions:

  1. What percentage of group A subgroups have anti-A1 present?


  2. Is the anti-A1 present in some A subgroups usually clinically significant?


  3. What is the typical appearance of mixed-field agglutination?


  4. What can cause mixed-field agglutination?


Further Reading

  • British Columbia Provincial Blood Coordinating Office. Technical resource manual for hospital transfusion services, ed 2. Vancouver: Provincial Blood Coordinating Office;2006. See CT.003 ABO group problem solving.
  • Harmening DM. Modern blood banking and transfusion practices. 4th ed. Philadelphia: FA Davis;1999.
  • Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications; 1998.
  • Vengelen-Tyler V, editor. Technical manual. 13th ed. Bethesda, MD: American Association of Blood Banks; 1999.