This case involves transfusing a patient who has a positive antibody screen with crossmatch-compatible RBC before the antibody has been identified. As a result the patient suffered a hemolytic transfusion reaction.
Pertinent issues include:
- Dosage as it relates to antibody screening
- Risk of releasing crossmatch-compatible units that are not antigen typed
- Why a patient with an antibody may have a false-negative antibody screen
- Antibody kinetics following 1o and 2o immune responses
- Best practices to preventing delayed hemolytic transfusion reactions (DHTR)