History
Mrs. E.M. is a 77 yr. old female admitted with
chest pain and anemia. She has been admitted several times over the
previous year for investigation of chronic gastrointestinal
bleeding.
- Pregnancies:
4
- Transfusion:
2 units of red blood cells transfused on each of
three occasions over the previous year. The most recent
transfusion was 4 months ago.
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Based on these results, an antibody investigation
was done.
Case Summary
and Quiz
After reviewing the case
summary, consider these questions.
1. Which antibodies were once classified as HTLA?
2. With which types of diseases are null Chido
and Rogers phenotypes associated?
3. Since anti-Ch and -Rg are considered to be
clinically insignificant, is it important to investigate and identify
them?
4. Has anti-Ch or anti-Rg ever caused a severe
transfusion reaction?
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Further Reading
Graphpad.
Online tool
for calculating p values
Westhoff CM, Sipherd BD, Wylie DE, Toalson LD. Severe
anaphylactic reactions following transfusions of platelets to a patient
with anti-Ch. Transfusion 1992 Jul-Aug;32(6):576-9. [ Medline
]
