Quiz
Answer (Question 2)
- Describe the course of alloimmunization to red cell antigens.
Primary alloimmunization becomes apparent by detection of antibody weeks or months after transfusion. Approximately 1 - 3% of transfused recipients develop detectable antibodies; the incidence increases in multi-transfused patients. Hemolysis does usually not occur with 1o immunization because donor red cells have disappeared before circulating antibody achieves a clinically significant level.
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