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Case B3: ABO Discrepancy Complicated by Transfusion

Case Report

History

Mr. VT is a 50-year-old male who has been admitted for elective surgery following a car accident. He had been admitted to another hospital 4 weeks earlier following the accident.

Tests

  • Two units of red cells are ordered for the surgery.

Discussion and Resolution 

bullet Case discussion, including interactive questions with feedback. 

bullet Resolution

QUIZ

After reviewing the case resolution, answer these questions:

1. What percentage of group A subgroups have anti-A1 present?
 
answer

2. Is the anti-A1 present in some A subgroups usually clinically significant?
 
answer

3. What is the typical appearance of mixed-field agglutination?
 
answer
4. What can cause mixed-field agglutination?
 
answer

 

Further Reading

  • British Columbia Provincial Blood Coordinating Office. Technical resource manual for hospital transfusion services, ed 2. Vancouver: Provincial Blood Coordinating Office;2006. See CT.003 ABO group problem solving. 

  • Harmening DM. Modern blood banking and transfusion practices. 4th ed. Philadelphia: FA Davis;1999.

  • Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications;1998.

  • Vengelen-Tyler V, editor. Technical manual. 13th ed. Bethesda, MD: American Association of Blood Banks;1999.
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