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Case B1: Positive DAT in a Neonate

Case Report

History

Mrs. RF is a 29-year-old female who has been admitted for delivery of her third child. She has no history of transfusion. History check reveals a group and screen was performed 11 months earlier.

Results from that admission:

  • O Rh negative
  • Antibody screen: negative by LISS IAT

A group and screen is ordered as a precaution and as a consequence of the difficult delivery of her second child. A healthy infant is delivered and the cord blood is sent to the lab for testing.

Tests

  • The laboratory SOP for maternal-fetal testing protocol requires an ABO/Rh and DAT on the cord blood.
  • A maternal group and screen is performed as ordered.

Discussion and Resolution 

bullet Case discussion, including interactive questions with feedback. 

bullet Resolution

Further Reading

  • British Columbia Provincial Blood Coordinating Office. Technical resource manual for hospital transfusion services. Vancouver: Provincial Blood Coordinating Office;2000. See RT.003 - Weak D typing.

  • Canadian Society for Transfusion Medicine. CSTM standards for transfusion medicine, 6th ed. Saskatoon: Canadian Society for Transfusion Medicine;1999.

  • Judd WJ. .Practice guidelines for prenatal and perinatal immunohematology, revisited (Transfusion 2001 Nov; 41(11): 1445-52).

  • Lopez-Plaza I. Immune-mediated hemolytic disease of the newborn.  ITx in Pittsburgh

  • Vengelen-Tyler V, editor. Technical manual. 13th ed. Bethesda, MD: American Association of Blood Banks;1999.
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